HU-210 CAS NO: 112830-95-2

HU-210 ndiye (--) enantiomer ya 11-OH-D 8-THC-DMH, yomwe ili ndi pafupifupi zochitika zonse za cannabinoids, pomwe (+) enantiomer, yotchedwa HU-211, siyikugwira ntchito ngati cannabinoid, koma imagwira ntchito ngati cannabinoid ngati mdani wa NMDA wokhala ndi zotsatira za neuroprotective.

HU-210 ikhoza kulimbikitsa kuchulukana, koma osati kusiyanitsa, kwa maselo amtundu wa embryonic hippocampal neural stem cell ndi ma progenitor cell poyambitsa CB 1 receptor, G i/o protein, ndi ERK signing motsatizana.Kuwonjezeka kwa mitsempha yamtunduwu kumasonyezanso kufunikira kotsutsana ndi nkhawa ndi zotsatira zotsutsa-depressive.

Pamodzi ndi zina zopangira cannabinoids, monga WIN 55,212-2 ndi JWH-133, HU-210 imateteza ku kutupa komwe kumayambitsidwa ndi matenda a Alzheimer's amyloid beta amyloid, kuphatikizapo kupewa kusokonezeka kwa chidziwitso ndi kutayika kwa zizindikiro za neuronal.Izi zotsutsa-kutupa zimayambitsidwa ndi kuyambitsa kwa cannabinoid zolandilira, zomwe zimalepheretsa kuyambitsa kwa ma cell otupa a microglia.Kuphatikiza apo, cannabinoids adathetseratu neurotoxicity yolumikizidwa ndi ma microglial cell activation mumitundu ya makoswe.

HU-210 ndi mankhwala opweteka kwambiri omwe ali ndi zotsatira zofanana ndi THC zachilengedwe.

Mkamwa LD50 wa HU-210 ndi 5,000mg/kg mu makoswe ndi 14,200mg/kg mu akalulu.LDLO (otsika kwambiri mlingo wakupha) wa HU-210 mwa anthu ndi 143mg/kg.LD50 ya caffeine imawerengedwa kuti ndi 150-200 mg / kg.Delta-8-THC LD50 sichinatsimikizidwe.Mu kafukufuku wa 1973, anyani ndi agalu omwe anapatsidwa 9,000 mg / kg ya Delta-8-THC anali osapha.