Human Choroinic Gonadotrophin HCG CAS:9002-61-3

Chorionic gonadotropin (hCG) yaumunthu ndi mahomoni a glycoprotein opangidwa ndi ma cell a placental endodermal.Ntchito yake yayikulu ndikulimbikitsa corpus luteum, yomwe imathandizira kutulutsa kwa estrogen ndi progesterone kosalekeza, kuti ilimbikitse mapangidwe a chiberekero cha decidual ndikupanga placenta kukula ndi kukhwima.Mwanayo atangoikidwa, maselo a blastoderm amayamba kutulutsa hCG, kotero kuti mimba imatha kutsimikiziridwa ndi hCG m'magazi kapena mkodzo.

Linapangidwa ndi 244 amino acid zotsalira, ndi molecular kulemera kwa 36.7kDa ndi kukula kwa 7.5 × 3.5 × 3 nm.Ndi heterodimer yokhala ndi α subunit yofanana ndi luteinizing hormone (LH), follicle-stimulating hormone (FSH) ndi thyrotropin (TSH), koma β subunit yosiyana.Gulu la α linali ndi zotsalira za amino acid 92, ndipo β subunit inali ndi zotsalira za amino acid 145.

hCG kaphatikizidwe akazi kwambiri kuchuluka pambuyo pa mimba, ndi kukhalapo kwa hCG mu plasma ndi mkodzo ndi chimodzi mwa zizindikiro oyambirira mimba ndi ntchito kuyezetsa mimba.

(1) Lili ndi ntchito ya FSH ndi LH kusunga nthawi ya moyo wa msambo corpus luteum ndi kupanga msambo corpus luteum kukhala gestational corpus luteum;

(2) Limbikitsani kununkhira kwa androgens mu estrogen, ndikulimbikitsa mapangidwe a progesterone;

(3) Kuletsa kukondoweza zotsatira za chomera lectin pa lymphocytes, anthu chorionic gonadotropin akhoza adsorbed padziko trophoblast maselo, kuti kupewa kuukira maselo a embryonic trophoblast ndi lymphocytes amayi;

(4) LH ntchito, pamaso pa fetal pituitary secrete LH, kumapangitsa fetal testis kutulutsa testosterone kulimbikitsa mwamuna kusiyana kugonana;Itha kulimbikitsanso chitukuko cha gonadal, amuna amatha kulimbikitsa mphamvu zama cell a testis mesenchymal, kuonjezera katulutsidwe ka mahomoni aamuna (testosterone).Ndikofunikira kwambiri pochiza odwala omwe ali ndi vuto la pituitary olowa, zomwe sizimangolimbikitsa kukula kwa gonad komanso kutulutsa kwa timadzi tating'onoting'ono, komanso kulimbikitsa kukula kwa mikhalidwe yachiwiri yogonana.

(5) Ikhoza kumangirira ku TSH receptor ya maselo a chithokomiro cha amayi ndikuyambitsa ntchito ya chithokomiro.