mankhwala apakatikati 99% ufa woyera CAS 86386-73-4 Fluconazol
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Zambiri Zoyambira
Fluconazole-D4 imawoneka ngati ufa wonyezimira wachikasu mpaka wachikasu ndipo ndi wonunkhira pang'ono ndi kukoma kowawa.
Imasungunuka mosavuta mu glacial acetic acid, methanol kapena ethanol, yosasungunuka m'madzi ndipo imakhala yosasungunuka mu etha pomwe imasungunuka ndi 137 ~ 141.6 ℃, kapena malo osungunuka kukhala 138~140 ℃ (yochokera ku ethyl acetate-hexane).
Kugwiritsa ntchito
Izi ndi za fluorinated triazole antifungal mankhwala ndi antifungal sipekitiramu kukhala ofanana ndi ketoconazole koma antifungal ntchito kukhala apamwamba kuposa ketoconazole.
Njira yake yochitirapo kanthu ndi kuletsa kwa gawo lofunikira la nembanemba ya fungal cell, ergosterol biosynthesis enzyme, kutsekereza kaphatikizidwe ka ergosterol ndikuphwanya kukhulupirika kwa khoma la cell, ndikulepheretsa kukula kwawo ndi kubereka.
Mankhwalawa ali ndi mphamvu zowononga tizilombo toyambitsa matenda a Candida albicans, Microsporum canis, Cryptococcus neoformans, histoplasma capsulatum ndi epidermophyton.
Chemical Properties
Fluconazole-D4 ndi Yoyera mpaka Yoyera Yolimba
Amagwiritsa Ntchito Fluconazole (F421000).Amagwiritsidwa ntchito ngati antifungal.
Amagwiritsa ntchito anticholinergic
Fluconazole-D4 imagwiritsidwa ntchito pochiza matenda oyamba ndi fungus.
Amagwiritsa ntchito triazole wide-spectrum antifungal agent.
Zizindikiro
Fluconazole (Diflucan) ikhoza kuyamwa bwino ndipo mwina imakhala yochepa kwambiri ya hepatotoxic kuposa ketoconazole, koma ndiyokwera mtengo kwambiri, kuganiziridwa kofunika chifukwa cha kutalika kwa chithandizo cha matenda a mafangasi ambiri.