Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Salt

GWIRITSANI NTCHITO

Tianeptine sodium mchere ndi tricyclic antidepressant, ndipo njira yake yochepetsera maganizo ndi yosiyana ndi tricyclic antidepressants.Ikhoza kuonjezera kubwereza kwa 5-HT mu danga la synaptic, ndipo ikhoza kukhala ndi zotsatira zopititsa patsogolo kayendedwe ka 5-HT neurons.Palibe kuyanjana kwa choline kapena adrenaline receptors.Mphamvu ya antidepressant ndi yofanana ndi tricyclic, koma kulolerana ndikwabwino kuposa tricyclic.Pazoyeserera zanyama, zitha kukulitsa zochitika zodziwikiratu zamaselo a piramidi mu hippocampus ndikufulumizitsa kuchira kwawo pambuyo poletsa ntchito.Chemicalbook idakulitsa kuyamwanso kwa serotonin ndi ma neurons mu cerebral cortex ndi hippocampus.Mayamwidwe a tineptine sodium m'matumbo am'mimba amakhala mwachangu komanso kwathunthu.Kugawa mwachangu, PPB mpaka 94%.Anagwiritsidwa ntchito kwathunthu mu chiwindi ndi β-oxidation ndi N-demethylation, ndipo chilolezo cha terminal T1 / 2 chinali chachifupi pa 2.5h.Mankhwala ochepa kwambiri (8%) adatulutsidwa mu impso, makamaka ma metabolites ake mumkodzo.Odwala omwe ali ndi vuto laimpso amachotsa T1/2 kwa nthawi yayitali ya 1.